Robert W Keane Selected Research

I-kappa B Kinase

10/2006	Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage.
12/2004	Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain.

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Robert W Keane Research Topics

Disease

25	Inflammation (Inflammations) 01/2024 - 12/2004
20	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2024 - 12/2004
12	Spinal Cord Injuries (Spinal Cord Injury) 01/2018 - 09/2002
7	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 04/2014
7	Wounds and Injuries (Trauma) 01/2023 - 03/2008
6	Neuroinflammatory Diseases 01/2024 - 04/2014
6	Stroke (Strokes) 10/2022 - 03/2009
5	Brain Injuries (Brain Injury) 01/2024 - 01/2016
5	Multiple Sclerosis 09/2020 - 01/2016
4	Infections 01/2023 - 05/2014
4	Lung Injury 01/2021 - 01/2017
3	Hyperoxia 05/2024 - 01/2017
3	Acute Lung Injury 01/2024 - 01/2018
3	Cognitive Dysfunction 06/2020 - 12/2011
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/2020 - 01/2016
3	Porcine Reproductive and Respiratory Syndrome (PRRS) 08/2014 - 07/2013
3	Contusions 03/2012 - 09/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2023 - 02/2012
2	COVID-19 01/2023 - 01/2020
2	Disease Progression 05/2020 - 01/2018
2	Brain Ischemia (Cerebral Ischemia) 01/2018 - 03/2009
2	Melanoma (Melanoma, Malignant) 04/2014 - 03/2012
2	Ischemia 01/2013 - 03/2009
2	Hypothermia 10/2012 - 10/2006
1	Eye Injuries (Eye Injury) 05/2024
1	Dementia (Dementias) 01/2024
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2024
1	Parkinson Disease (Parkinson's Disease) 06/2023
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2023
1	Ischemic Stroke 10/2022
1	Lupus Nephritis 01/2022
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022
1	Alcoholic Fatty Liver 11/2020
1	Liver Diseases (Liver Disease) 11/2020
1	Psoriatic Arthritis 01/2020
1	Ventilator-Induced Lung Injury 01/2020
1	Central Nervous System Diseases (CNS Diseases) 01/2020
1	Disseminated Intravascular Coagulation 01/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2020
1	Vascular Remodeling 01/2017
1	Bronchopulmonary Dysplasia 01/2017

Drug/Important Bio-Agent (IBA)

46	InflammasomesIBA 01/2024 - 03/2008
27	Proteins (Proteins, Gene)FDA Link 05/2024 - 10/2006
12	Biomarkers (Surrogate Marker)IBA 01/2024 - 01/2018
12	CytokinesIBA 01/2023 - 03/2008
8	Interleukin-18 (Interleukin 18)IBA 06/2023 - 03/2009
8	InterleukinsIBA 01/2023 - 03/2009
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 12/2004
4	NLR ProteinsIBA 01/2016 - 07/2013
3	Monoclonal AntibodiesIBA 05/2024 - 01/2020
3	Type I Tumor Necrosis Factor ReceptorsIBA 01/2020 - 10/2006
3	Pattern Recognition ReceptorsIBA 08/2014 - 07/2013
3	CaspasesIBA 02/2012 - 09/2002
3	LigandsIBA 05/2007 - 12/2004
2	Multiprotein ComplexesIBA 01/2023 - 01/2016
2	Interleukin-6 (Interleukin 6)IBA 10/2022 - 01/2020
2	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2021 - 01/2020
2	Enoxaparin (Lovenox)FDA LinkGeneric 01/2021 - 01/2020
2	NucleotidesIBA 01/2016 - 12/2011
2	Interleukin-1 (Interleukin 1)IBA 01/2016 - 08/2011
2	DNA (Deoxyribonucleic Acid)IBA 04/2014 - 03/2014
2	Probenecid (Benemid)FDA LinkGeneric 04/2014 - 12/2012
2	Adenosine Triphosphate (ATP)IBA 03/2014 - 07/2013
2	Peptides (Polypeptides)IBA 09/2013 - 09/2002
2	X-Linked Inhibitor of Apoptosis ProteinIBA 07/2009 - 10/2006
2	Neutralizing AntibodiesIBA 07/2009 - 03/2009
2	Interleukin-1beta (Interleukin 1 beta)IBA 07/2009 - 03/2008
2	NF-kappa B (NF-kB)IBA 10/2006 - 12/2004
2	I-kappa B KinaseIBA 10/2006 - 12/2004
1	Oxygen (Dioxygen)IBA 05/2024
1	Retinaldehyde (Retinal)IBA 05/2024
1	Protein Isoforms (Isoforms)IBA 05/2024
1	Conditioned Culture MediaIBA 01/2024
1	NeurograninIBA 01/2024
1	tau Proteins (tau Protein)IBA 01/2024
1	Complement System Proteins (Complement)IBA 09/2023
1	SynucleinsIBA 06/2023
1	Interleukin-13IBA 10/2022
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2022
1	Vascular Endothelial Growth Factor CIBA 10/2022
1	Interleukin-16 (Interleukin 16)IBA 10/2022
1	Interleukin-2 (IL2)IBA 10/2022
1	Interleukin-4 (Interleukin 4)IBA 10/2022
1	Interleukin-8 (Interleukin 8)IBA 10/2022
1	Galectin 3 (LGALS3)IBA 11/2020
1	Dacarbazine (DIC)FDA LinkGeneric 01/2020
1	Type II Tumor Necrosis Factor ReceptorsIBA 01/2020
1	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketoneIBA 01/2019
1	interleukin-1beta-converting enzyme inhibitorIBA 01/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2018
1	NSC 23766IBA 01/2017
1	Saline SolutionIBA 01/2017
1	Caspase 1 (ICE Protease)IBA 01/2016
1	Pathogen-Associated Molecular Pattern MoleculesIBA 08/2014
1	C-Type Lectins (C-Type Lectin)IBA 08/2014

Therapy/Procedure

4	Therapeutics 01/2020 - 12/2012
2	Intraperitoneal Injections 01/2019 - 01/2017
1	Microelectrodes 01/2023
1	Electrodes (Electrode) 01/2023
1	Artificial Respiration (Mechanical Ventilation) 01/2020